Director, Antibody Discovery

Job summary

<p><strong>Position Summary: </strong></p> <p>Quotient is seeking a Director or Senior Director of Antibody Discovery. This role will define and lead Quotient’s antibody discovery strategy; leading the delivery of therapeutic antibody projects in addition to Quotient’s antibody drug discovery platform build through the deployment of cutting-edge technologies.

Benefits

Qualifications

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• p><u>Essential</u></p>
• li>Proven experience advancing protein therapeutics through drug discovery phases to development.</li>
• li>Expertise in structure-based protein engineering and design of antibodies including (multispecifics, Fc engineering, fusion proteins etc)</li>
• li>Skilled in antibody engineering, including use of in silico, structure-based, and AI/ML approaches to sequence/CDR design, use of display

Responsibilities

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• li>Provide balanced expert advice on the feasibility of antibody tractable targets and the conception of high-value drug molecules</li>
• li>Present antibody discovery strategies to internal R&D committees to justify capital commitment in new programs</li>
• li>Drive decision making on construct design, format and developability for new antibody programs according to Target Product Profile specifications</li>
• li>Independently carry out lead sequence and format optimizations utilizing rational, structure-based and in silico/AI/ML design approaches</li>
• li>Drive rapid optimization of novel antibody and protein therapeutics through iterative design, build, test, and learn cycles</li>
• li>Model best matrix leadership behaviours and support an emphasis on enterprise leadership across the company</li>
• li>Build and maintain networks of external experts to pressure-test hypotheses and refine strategies</li>
• li>Serve as a specialist antibody discovery expert within Quotient’s drug discovery team and across the company.</li>
• li>Contribute to broader corporate strategy, BD evaluations, and exploratory platform initiatives</li>
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